Role of Thyroidectomy in Recurrent Laryngeal Carcinoma

No Thumbnail Available
Authors
Brunet, A
Tornari, C
Ezebuiro, A
Kennedy, R
Connor, S
Oakley, E.J
Jeannon, J-P
Arora, A
Rovira, A
Simo, R
Issue Date
2022
Type
Published Abstract
Language
Keywords
Research Subject Categories::MEDICINE::Surgery , Research Subject Categories::MEDICINE::Surgery::Otorhinolaryngology
Research Projects
Organizational Units
Journal Issue
Alternative Title
Abstract
Abstract Objective: Management of recurrent laryngeal cancer presents a major challenge, and salvage laryngectomy is complicated by previous oncologic treatments. Thyroidectomy as part of salvage laryngectomy adds a nonnegligible degree of morbidity. The purpose of this study is to assess the rate of thyroid gland invasion in patients undergoing salvage laryngectomy to determine relevant predictive factors. Study design: Case series with chart review. Setting: Department of Otorhinolaryngology, Head and Neck Surgery, Guy's Hospital, London, United Kingdom. Methods: A retrospective review of patients undergoing salvage laryngectomy between 2009 and 2019 was undertaken. Preoperative cross-sectional imaging and histopathological analysis were performed to define evidence and predictors of thyroid gland invasion (TGI). Results: Fifty-one patients had salvage laryngectomy. Histological evidence of TGI was found in 4 patients (7.8%). No significant relationship was found between histological TGI and subsite of primary carcinoma, degree of differentiation, T staging, or radiological TGI. Preoperative computed tomography had a high negative predictive value for TGI. Conclusion: Thyroidectomy should be carefully considered in patients undergoing salvage laryngectomy, and its extent should be defined on an individual basis. Total thyroidectomy should not routinely be performed in salvage laryngectomy or pharyngolaryngectomy in patients with no preoperative radiological evidence of TGI on cross-sectional imaging, unless there is intraoperative evidence of TGI. Keywords: laryngeal squamous cell carcinoma; laryngectomy; thyroid gland. PubMed Disclaimer Similar articles Incidence of thyroid gland invasion in advanced laryngeal cancers and its impact on disease-specific survival; a retrospective review at a tertiary care center. Muhammad T, Dhanani R, Mohtasham S, Hussain M, Faisal M, Malik KI, Jamshed A, Hussain R. Acta Otolaryngol. 2020 Oct;140(10):882-885. doi: 10.1080/00016489.2020.1778786. Epub 2020 Jul 7. PMID: 32633590 Review. The incidence of thyroid gland invasion in advanced laryngeal squamous cell carcinoma. Al-Hakami HA, Al Garni MA, AlSubayea H, AlOtaibi Y, Neazy A, Jameel W, Albouq M, Alnufaie A, Fatani N. Braz J Otorhinolaryngol. 2021 Sep-Oct;87(5):533-537. doi: 10.1016/j.bjorl.2019.11.003. Epub 2019 Dec 9. PMID: 31879196 Free PMC article. Management of the thyroid gland during laryngectomy. Li SX, Polacco MA, Gosselin BJ, Harrington LX, Titus AJ, Paydarfar JA. J Laryngol Otol. 2017 Aug;131(8):740-744. doi: 10.1017/S0022215117001244. Epub 2017 Jun 8. PMID: 28592347 Free PMC article. Evidence-based management of the thyroid gland during a total laryngectomy. Gorphe P, Ben Lakhdar A, Tao Y, Breuskin I, Janot F, Temam S. Laryngoscope. 2015 Oct;125(10):2317-22. doi: 10.1002/lary.25417. Epub 2015 Jun 24. PMID: 26108451 Thyroid gland management in total laryngectomy: meta-analysis and surgical recommendations. Mendelson AA, Al-Khatib TA, Julien M, Payne RJ, Black MJ, Hier MP. Otolaryngol Head Neck Surg. 2009 Mar;140(3):298-305. doi: 10.1016/j.otohns.2008.10.031. PMID: 19248932 Review. See all similar articles Publication types Research Support, Non-U.S. Gov't MeSH terms Carcinoma, Squamous Cell* / pathology Humans Laryngeal Neoplasms* / pathology Laryngeal Neoplasms* / surgery Laryngectomy / methods Neoplasm Invasiveness Retrospective Studies Salvage Therapy Thyroidectomy Related information MedGen Grants and funding DH_/Department of Health/United Kingdom LinkOut - more resources Full Text Sources Atypon Ovid Technologies, Inc. Wiley
Description
Citation
Brunet A, Tornari C, Ezebuiro A, Kennedy R, Connor SEJ, Oakley R, Jeannon JP, Arora A, Rovira A, Simo R. Role of Thyroidectomy in Recurrent Laryngeal Carcinoma. Otolaryngol Head Neck Surg. 2022 May;166(5):894-900. doi: 10.1177/01945998211033523. Epub 2021 Aug 17. PMID: 34403272.
Publisher
License
Journal
Volume
Issue
URI
https://pubmed.ncbi.nlm.nih.gov/34403272/
 https://hdl.handle.net/20.500.12847/295
PubMed ID
DOI
10.1177/01945998211033523
ISSN
https://aao-hnsfjournals.onlinelibrary.wiley.com/doi/10.1177/01945998211033523
EISSN
Collections
Clinical Service Line 04 - Opthalmology, Dermatology, Plastics, Outpatients, ENT/Audiology, OMFT/Dental