Liver diseases in pregnancy

Lim, E; Mouyis, M; MacKillop, L

Liver diseases in pregnancy

Authors

Lim, E

Mouyis, M

MacKillop, L

Issue Date

2021

Type

Scientific Paper

Keywords

Research Subject Categories::MEDICINE::Surgery::Obstetrics and women's diseases::Obstetrics and gynaecology

Abstract

Abstract Liver disease in pregnancy can be related to a pre-existing condition (such as autoimmune liver disease) or arise as a consequence of pregnancy. In women with pre-existing disease, pre-pregnancy counselling is important to discuss the potential complications that may occur during pregnancy and how best to manage these. Acute fatty liver of pregnancy and HELLP (haemolysis, elevated liver enzymes and low platelets) syndrome are pregnancy-related liver diseases and are considered obstetric emergencies. Women with liver dysfunction need appropriate investigations, including blood tests and imaging. They should be managed as part of a multidisciplinary team with obstetricians, obstetric anaesthetists, specialist midwives, gastroenterologists and obstetric physicians. Keywords: imaging; liver disease; obstetric emergencies; pregnancy. © Royal College of Physicians 2021. All rights reserved. PubMed Disclaimer Similar articles Pregnancy-Associated Liver Diseases. Terrault NA, Williamson C. Gastroenterology. 2022 Jul;163(1):97-117.e1. doi: 10.1053/j.gastro.2022.01.060. Epub 2022 Mar 8. PMID: 35276220 Review. Severe hepatic dysfunction in pregnancy. Rahman TM, Wendon J. QJM. 2002 Jun;95(6):343-57. doi: 10.1093/qjmed/95.6.343. PMID: 12037242 Review. [The pregnant patient with acute liver disease]. Siemens FC, Visser W, Metselaar HJ, Zondervan PE, de Groot CJ. Ned Tijdschr Geneeskd. 2002 Aug 3;146(31):1433-7. PMID: 12190007 Dutch. Pregnancy-associated severe liver dysfunction. Steingrub JS. Crit Care Clin. 2004 Oct;20(4):763-76, xi. doi: 10.1016/j.ccc.2004.05.006. PMID: 15388201 Review. Liver disease in pregnancy. Williamson C, Nelson-Piercy C. Br J Hosp Med. 1997 Sep 3-16;58(5):213-6. PMID: 9488818 No abstract available. See all similar articles Cited by Physiology of pregnancy and oral local anesthesia considerations. Zhou X, Zhong Y, Pan Z, Zhang J, Pan J. PeerJ. 2023 Jun 29;11:e15585. doi: 10.7717/peerj.15585. eCollection 2023. PMID: 37404472 Free PMC article. Review. Utility of Doppler-Ultrasound and Liver Elastography in the Evaluation of Patients with Suspected Pregnancy-Related Liver Disease. Serra C, Dajti E, De Molo C, Montaguti E, Porro A, Seidenari A, Angilletta E, Bernardi V, Salsi G, Bakken SM, Montagnani M, Mazzella G, Azzaroli F. J Clin Med. 2023 Feb 19;12(4):1653. doi: 10.3390/jcm12041653. PMID: 36836188 Free PMC article. Imaging of Acute Abdominopelvic Pain in Pregnancy and Puerperium-Part II: Non-Obstetric Complications. Masselli G, Bonito G, Gigli S, Ricci P. Diagnostics (Basel). 2023 Sep 11;13(18):2909. doi: 10.3390/diagnostics13182909. PMID: 37761275 Free PMC article. Review. Key Components of Successful Management of Acute Fatty Liver of Pregnancy: A Case Report and Literature Review. Patidar R, Gowdra Revannasiddappa K, Ghazanfer M. Cureus. 2024 Feb 9;16(2):e53911. doi: 10.7759/cureus.53911. eCollection 2024 Feb. PMID: 38465073 Free PMC article. In response to crisis, is versatility a reward or a necessity. Emmanuel A. Clin Med (Lond). 2021 Sep;21(5):e433. doi: 10.7861/clinmed.ed.21.5.1. PMID: 34507925 Free PMC article. No abstract available. See all "Cited by" articles References Ch'ng CL, Morgan M, Hainsworth I, Kingham JG. Prospective study of liver dysfunction in pregnancy in Southwest Wales. Gut 2002;51:876–80. - PMC - PubMed Bacq Y, Zarka O, Brechot J, et al. . Liver function tests in normal pregnancy: a prospective study of 103 pregnant women and 103 matched controls. Hepatology 1996;23:1030–2. - PubMed Committee on Obstetric Practice. Committee opinion no. 723: Guidelines for diagnostic imaging during pregnancy and lactation. Obstet Gynecol 2017;130:e210–6. - PubMed García-Romero C, Guzman C, Cervantes A, Cerbón M. Liver disease in pregnancy: Medical aspects and their implications for mother and child. Ann Hepatol 2019;18:553–62. - PubMed Royal College of Obstetrics and Gynaecology . The management of nausea and vomiting of pregnancy and hyperemesis gravidarum. RCOG, 2016. Show all 28 references MeSH terms Female HELLP Syndrome* / diagnosis HELLP Syndrome* / therapy Humans Liver Liver Diseases* / diagnosis Liver Diseases* / therapy Pregnancy Pregnancy Complications* / diagnosis Pregnancy Complications* / therapy Related information MedGen LinkOut - more resources Full Text Sources ClinicalKey Elsevier Science Europe PubMed Central HighWire Ovid Technologies, Inc. PubMed Central Medical MedlinePlus Health Information

Citation

Lim E, Mouyis M, MacKillop L. Liver diseases in pregnancy. Clin Med (Lond). 2021 Sep;21(5):e441-e445. doi: 10.7861/clinmed.2021-0497. PMID: 34507927; PMCID: PMC8439517.