Disseminated tuberculosis is associated with more false negative interferon gamma release assay results compared to localized tuberculosis
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Authors
Shah, S
Eisenhut, M
Issue Date
2022
Type
Scientific Paper
Language
Keywords
Research Subject Categories::MEDICINE::Dermatology and venerology,clinical genetics, internal medicine::Internal medicine::Lung diseases
Alternative Title
Abstract
Background: Active tuberculosis has been associated with false negative interferon gamma release assay (IGRA) results. This may relate to a suppression of the interferon gamma response associated with a more extensive Mycobacterium (M.) tuberculosis infection.
Objective: To determine whether disseminated M. tuberculosis infection is associated with a higher rate of false negative IGRA results compared to localized tuberculosis.
Methods: In a systematic review of published individual patient data we compared IGRA results in patients with disseminated tuberculosis as evident from a diagnosis of miliary and/or central nervous system (CNS) tuberculosis with interferon gamma release assay results in patients with lymphnode tuberculosis.
Results: We identified 38 reports from Pubmed, EMBASE and Cochrane Library data bases containing individual patient data on 68 patients, 19 with lymph node tuberculosis and 49 with miliary and/or CNS tuberculosis. There was do difference in mean age, immunosuppressive co-morbidity or medication or confirmation by culture or PCR testing between the two groups. In patients with miliary and/or CNS tuberculosis 26.5% had a false negatie IGRA result compared to 5.2% of patients with lymph node tuberculosis (p<0.05). There was no difference in indeterminate results between groups.
Conclusions: Disseminated tuberculosis may be associated with an increased rate of false negative interferon gamma release assay results compared to localized tuberculosis.
Description
Citation
Shah, S. and Eisenhut, M. (2022) Disseminated tuberculosis is associated with more false negative interferon gamma release assay results compared to localized tuberculosis. European Respiratory Journal. 60(Suppl. 66), p. 63. DOI: 10.1183/13993003.congress-2022.63