Current guidelines in the surgical management of hereditary colorectal cancers
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Authors
Kudchadkar, S.
Ahmed, S.
Mukherjee, T.
Sagar, J.
Issue Date
2022
Type
Scientific Paper
Language
Keywords
Research Subject Categories::MEDICINE::Surgery , Research Subject Categories::MEDICINE::Surgery::Oncology , Research Subject Categories::MEDICINE::Dermatology and venerology,clinical genetics, internal medicine::Internal medicine::Gastroenterology
Alternative Title
Abstract
Abstract
Incidence of colorectal cancer (CRC) is on rise. While approximately 70% of all CRC cases are sporadic in nature, 20%-25% have familial aggregation and only < 5% is hereditary in origin. Identification of individuals with hereditary predilection for CRC is critical, as it has an impact on their overall surgical management including surgical timing, approach & technique and determines the role of prophylactic surgery and outcome. This review highlights the concept of hereditary CRC, provides insight into its molecular basis, possibility of its application into clinical practice and emphasizes the current treatment strategies with surgical management, based on the available international guidelines.
Keywords: Colorectal cancer; Familial adenomatosis polyposis; Immunohistochemistry; Lynch syndrome; Metachronous colon cancer.
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
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Conflict of interest statement
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
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Description
Citation
Kudchadkar S, Ahmed S, Mukherjee T, Sagar J. Current guidelines in the surgical management of hereditary colorectal cancers. World J Gastrointest Oncol. 2022 Apr 15;14(4):833-841. doi: 10.4251/wjgo.v14.i4.833. PMID: 35582097; PMCID: PMC9048527.
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https://www.wjgnet.com/1948-5204/full/v14/i4/833.htm