Correlation Between Morphological Patterns and Multidetector Computed Tomography (MDCT) Enhancement Patterns in Gallbladder Carcinoma With Locoregional Infiltration

Meena, A; Kumari, M; Anand, R; Solanki, R.S; Nair, N; Pathania, O.P; Nangia, A; Prasad, S.N

Correlation Between Morphological Patterns and Multidetector Computed Tomography (MDCT) Enhancement Patterns in Gallbladder Carcinoma With Locoregional Infiltration

Authors

Meena, A

Kumari, M

Anand, R

Solanki, R.S

Nair, N

Pathania, O.P

Nangia, A

Prasad, S.N

Issue Date

2024

Type

Scientific Paper

Keywords

Research Subject Categories::MEDICINE::Surgery::Oncology

Abstract

Abstract Objective: This study aimed to explore the correlation between morphological patterns and multidetector computed tomography (MDCT) enhancement patterns in gallbladder cancer with locoregional infiltration among the Indian population. Methodology: This cross-sectional study was conducted across the pathology, surgery, and radiodiagnosis departments at Lady Hardinge Medical College, New Delhi. It focused on patients diagnosed with gallbladder disorders during the study period, identified through clinical examination or MDCT. Each patient underwent a fasting computed tomography (CT) scan using a Philips Brilliance 40-slice MDCT scanner. A neutral oral contrast, consisting of 1200 ml of water and 300 ml of 20% w/v mannitol, was administered. Additionally, for two patients suspected of gallbladder perforation extending to the pyloric duodenal area, a 2% non-ionic water-soluble contrast agent was used. Results: The study found no statistically significant association between intraluminal polypoidal growth and other infiltration sites. However, wall thickening was significantly associated with various infiltration sites, including the liver, colon, bile ducts, and vascular structures. A strong positive correlation was observed between portovenous hyperenhancement and all examined morphological patterns, with the most notable correlations found with non-contrast CT (NCCT) hypo-isoenhancement. Conversely, arterial hyperenhancement showed an inverse relationship with some morphological patterns, with correlation coefficients of -0.60 for intraluminal polypoidal growth versus gallbladder wall thickening and mass replacement of the gallbladder versus intraluminal polypoidal growth. Conclusion: Gallbladder cancer frequently leads to the replacement or damage of the gallbladder, with both focal and diffuse wall thickening being common findings. Hypo-isoenhancement was the most prevalent imaging pattern, while hyperenhancement was less common. Although intraluminal polypoidal growth did not significantly correlate with metastasis, wall thickening was significantly associated. These results emphasize the importance of specific imaging patterns in assessing the severity of gallbladder cancer and informing treatment strategies. Keywords: enhancement patterns; gallbladder cancer; locoregional; morphological patterns; multidetector computed tomography. Copyright © 2024, Meena et al. PubMed Disclaimer Conflict of interest statement Human subjects: Consent was obtained or waived by all participants in this study. Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital issued approval ECHR/PR/2011/29. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. Similar articles Role of Multidetector Computed Tomography (MDCT) in Evaluation of Gallbladder Malignancy and its Pathological Correlation in an Indian Rural Center. Jindal G, Singal S, Nagi B, Mittal A, Mittal S, Singal R. Maedica (Bucur). 2018 Mar;13(1):55-60. PMID: 29868141 Free PMC article. Panorama of multidetector-row computed tomography findings of carcinoma gall bladder - A retrospective observational study. Mohakud S, Sidhu S, Deep N, Naik S. J Cancer Res Ther. 2022 Apr-Jun;18(3):661-667. doi: 10.4103/jcrt.jcrt_235_21. PMID: 35900538 Pixel to Pathology: A Prospective Cross-Sectional Study on the Role of Multidetector Computed Tomography in the Evaluation of Malignant Large Bowel Lesions With Histopathological Correlation. Prathapan L, Rama Krishnan KK, Bala P, T P. Cureus. 2024 Oct 10;16(10):e71200. doi: 10.7759/cureus.71200. eCollection 2024 Oct. PMID: 39525180 Free PMC article. Gallbladder carcinoma: causes of misdiagnosis at CT. Kim SW, Kim HC, Yang DM, Ryu JK, Won KY. Clin Radiol. 2016 Jan;71(1):e96-109. doi: 10.1016/j.crad.2015.10.016. Epub 2015 Nov 18. PMID: 26602932 Review. Imaging patterns of wall thickening type of gallbladder cancer. Soundararajan R, Marodia Y, Gupta P, Rana P, Chhabra M, Kalage D, Dutta U, Sandhu M. 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Citation

Meena A, Kumari M, Anand R, Solanki RS, Nair N, Pathania OP, Nangia A, Prasad SN. Correlation Between Morphological Patterns and Multidetector Computed Tomography (MDCT) Enhancement Patterns in Gallbladder Carcinoma With Locoregional Infiltration. Cureus. 2024 Aug 20;16(8):e67266. doi: 10.7759/cureus.67266. PMID: 39301356; PMCID: PMC11412273.