Il-17 Or Tnf Inhibitors - Real World Impact of Shared Decision Making in a Nurse Led Biologics Service
No Thumbnail Available
Authors
Begum, J
Nissar, M
Issue Date
2023
Type
Published Abstract
Language
Keywords
Research Subject Categories::MEDICINE::Dermatology and venerology,clinical genetics, internal medicine::Internal medicine::Rheumatology
Alternative Title
Abstract
Background: Since the availability of anti TNF biosimilars and the push from
reimbursement panels to use them first line, real world data regarding therapeutic
choice in biologic naive population is sparse.
Objectives: Evaluate the reasons for nurse led service choosing IL17 antago nists in biologic naïve SpA patients, in a shared decision making model, despite
the availability of cheaper anti TNF biosimilar.
Methods: We conducted a retrospective analysis of our electronic register for
people with PsA and AS from 1994 up to and including April 2022 at our univer sity teaching hospital. We had access to full patient records including details on
co-morbidities, drugs and disease management. All patients were evaluated in
biologics service led by clinical specialist nurses.
Results: PsA. 90 patients were prescribed Secukinumab since its availability in
the UK. Mean age was 51 yrs (24-80) and 56 (62%) were women. All were pre scribed since the adoption of Adalimumab biosimilar. Median duration of therapy
was 551 days (62-1284). Mean TJC and SJC were 8.14 (1-64) and 3.15 (1-57) at
initiation which improved at six months to 6.28 (1-46) and 2.77 (1-18) respectively.
24 (27%) were biologic naïve; 18 had it for better efficacy (six had axial disease,
four with enthesitis and eight with concomitant moderate to severe psoriasis) and
six for relative anti TNF contraindications including three with treated solid organ
neoplasms, one with BMI>35 and two for concurrent chronic infections including
HIV. AS. 47 patients were prescribed Secukinumab. Mean age was 54 (27-79)
and half were women. Median duration of therapy was 679 days (51-1154). Mean
BASDAI was 3.3 (0-9.2) at initiation which improved to 2.1 (0-7.5). 11 (23%) were
biologic naïve; five had it for better efficacy and six for relative anti TNF contraindications including three with treated cancers, two with latent TB and one for MS.
Conclusion: To our knowledge this is the first dedicated retrospective review of
a large real world spondyloarthritis cohort evaluating reasons for biologic choice.
Nearly a quarter of patients were prescribed Secukinumab prior to cheaper adalimumab biosimilar despite it being commissioned first choice agent in the region.
Clinicians including nurse specialists chose it for better efficacy in various SpA
domains. Relative contraindication to anti TNF drugs, which would not have been
considered significant in the past, was the second reason. Efficacy and safety
outcomes were comparable to other biologics. This confirms that shared decision making process demands flexibility and limiting choice goes against clinical acumen and patient preference. Opting only for lower drug acquisition tariff is unlikely
to be cost effective as the disease progresses whilst patients struggle with inappropriate prescription and thus delay biologics which are more likely to be efficacious
and retained longer. Hence there is an urgent need to review prescribing guidelines
to allow earlier employment of appropriate advanced therapies in the treatment
paradigm with significant benefits to both patients and the health economy
Description
Citation
Annals of the Rheumatic Diseases 82, pp. 932-933